Biochemical and Spectral Analysis of Roridin A Toxin and Copper (I) Nicotinate Complex as Antidote on Male Rat Liver

M. Ismail, Nabawia; M. Elsawi, Nagwa; M.Gashlan, Hana; M. Ali, Ahmed

doi:10.18576/jpac/030206

Biochemical and Spectral Analysis of Roridin A Toxin and Copper (I) Nicotinate Complex as Antidote on Male Rat Liver

Document Type : Original Article

Authors

¹ Chemistry Department, Faculty of Science, Sohag University, Sohag 82524, Egypt.

² Biochemistry Department, Faculty of Science, King Abdulaziz University, Jadda, kingdom of Saudi Arabia.

³ Chemistry Department, Faculty of Science, Al –Azhar University, Assiut Branch, Egypt.

10.18576/jpac/030206

Abstract

This work has been designed to evaluate the curative effect of copper (I) –nicotinate complex on the hepatotoxicity of Roridin A in male rats as well as the study of the spectral analysis of this complex. Healthy young male albino rats (n=40) were exposed to a single dose of Roridin A (60 μg/kg body weight) and scarified and another group was treated with the copper (I) –nicotinate complex. Such intoxication resulted in some biochemical parameters such as ALP, GGT, TAS, Ferritin and AFP. Finally, Copper (I)-Nicotinate complex reduced many undesired changes of liver tissue and this improvement was predicted since this complex has been confirmed previously as a therapeutic agent against induced mycotoxins as Roridin A.

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