Development of a new indirect method for the determination of Trifluuperazine HCl in pharmaceutical formulations.

Document Type : Original Article

Authors

1 College of Science University of Mosul, Mosul, Iraq

2 Department of Chemistry / College of Science University of Mosul, Mosul, Iraq

Abstract

Abstract: The estimation  of triflouperazine hydrochloride in pure and dosage forms has been developed using a simple spectrophotometric approach. The method employs an, oxidation-reduction reaction with 4,7diphenyi 1,10phenanthroline in the presence and  Iron(II) ammonium sulfate in the present   Cerric Sulfite  to produce a red-violet colored product with a maximum absorbance of 533nm.. The a molar absorptivity of 0.700x104 L.mole -1.cm-1, Beer's law is followed over a concentration range of 1.25-62.5 µg ml-1. The proposed approach was successfully used to determine triflouperazine hydrochloride in tablets. For the determination of trace quantities of TFPH, a simple, fast, exact, and sensible spectrophotometric approach has been established. Based on its, an oxidation-reduction reaction with 4-7 diphenyl 1,10phenanthroline  and iron(II) ammonium sulfate in the present ceric sulfite  as  the oxidizing agent serric sulphatr  , in aqueous solution The proposed method  has been effectively applied to pharmaceutical tablets.

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