Novel Biodegradable Pseudopolyrotaxane as Drug Carrier for Sulfamethazine: Synthesis, Characterization and Antimicrobial Efficacy

Hemat, M. Dardeer; Hany, A. Abdel Atty; Marwa, El. Hassan; Mohamad, A. Rasslan

doi:10.18576/jpac/080201

Novel Biodegradable Pseudopolyrotaxane as Drug Carrier for Sulfamethazine: Synthesis, Characterization and Antimicrobial Efficacy

Document Type : Original Article

Authors

¹ Department of Chemistry, Faculty of Science, South Valley University, Qena, 83523, Egypt

² Department of Medical Microbiology and Immunology, Faculty of Medicine, South Valley University, Qena, 83523, Egypt

³ : Department of Chemistry, Faculty of Science, Aswan University, Aswan, Egypt

10.18576/jpac/080201

Abstract

Polymers are widely used in pharmaceutical applications to improve the physical properties of drugs. At present time polyrotaxanes which contain cyclodextrin have significant uses in different fields particularly in drug delivery. Antibiotics are type of drugs used in medical treatment of bacterial infections but often have some side effects. In this study we aim to improve the physicochemical and efficiency properties of sulfamethazine drug (D) by loading into the prepared pseudopolyrotaxane, Chitosan/β-CD. The chemical structure of the obtained polymers and the drug after loading into the pseudopolyrotaxane Chitosan/β-CD/D were confirmed by utilizing the spectral analysis FT-IR, 1H-NMR. The morphological characterizations of the products were examined by SEM, the crystallinity of the products was investigated by XRD. Minimal inhibitory concentration (MIC) values of sulfamethazine, Chs/β-CD and Chs/β-CD/D determined against some Gram-negative and Gram-positive bacteria (E. coli, S. aureus). The results of this study established that loading sulfamethazine on the newly designed polymer not only showed higher antimicrobial and antibiotic efficacy compared to the pure drug, but also modified the physical and the chemical properties of the sulfamethazine drug itself.

--

Keywords