1
Departmentof Chemistry, Faculty of Science, Benghazi 1 University, Libya
2
Department of Botany, Faculty of Science, Benghazi University, Libya
10.18576/jpac/070102
Abstract
Treatment of a mixture of 3-methyl-1-phenylpyrazol-5-one 1 with a diversity of aromatic aldehydes and piperidine in absolute ethanol (24 h at 0 ºC) gave products in good yields. Biological screening of the synthesized derivatives for their antimicrobial activity against various bacteria (gram positive and gram negative) as well as against fungi have been evaluated, where derivatives 3 and 11 were found to be the most potent. Characterization of all the formed derivatives was emphasized by melting point determination, NMR data in addition to their mass spectra.
Shaglof, A., F. Ali, M., & Elzlatene, H. (2021). Synthesis and Evaluation of Biological Activity of Pyrazolone Compounds. Journal of Pharmaceutical and Applied Chemistry, 7(1), 8-22. doi: 10.18576/jpac/070102
MLA
Ahlam Shaglof; Mohamad F. Ali; Hend Elzlatene. "Synthesis and Evaluation of Biological Activity of Pyrazolone Compounds". Journal of Pharmaceutical and Applied Chemistry, 7, 1, 2021, 8-22. doi: 10.18576/jpac/070102
HARVARD
Shaglof, A., F. Ali, M., Elzlatene, H. (2021). 'Synthesis and Evaluation of Biological Activity of Pyrazolone Compounds', Journal of Pharmaceutical and Applied Chemistry, 7(1), pp. 8-22. doi: 10.18576/jpac/070102
VANCOUVER
Shaglof, A., F. Ali, M., Elzlatene, H. Synthesis and Evaluation of Biological Activity of Pyrazolone Compounds. Journal of Pharmaceutical and Applied Chemistry, 2021; 7(1): 8-22. doi: 10.18576/jpac/070102
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