In Vitro Antiproliferative and Antimicrobial Activity of 11-Epiartapshin Compound Isolated from SeriphidiumHerba-alba

M. El-Wassimy, M.Taher; M. Ahmed, Mehawed; H. H. Younes, Sabry; Elamir F. Hegazy, Mohamed-

doi:10.18576/jpac/040210

In Vitro Antiproliferative and Antimicrobial Activity of 11-Epiartapshin Compound Isolated from SeriphidiumHerba-alba

Document Type : Original Article

Authors

¹ Chemistry Department, Faculty of Science, Sohag University, Sohag 82524, Egypt.

² PhytochemistryDepartment, National Research Centre, Giza 12622, Egypt.

10.18576/jpac/040210

Abstract

Seriphidium herba-alba (Asteraceae family) was known for its therapeutic and medicinal properties, it was used in both traditional and modern medicine. 11-Epiartapshin was isolated from S. herba-alba. The structure of the compound was elucidated by means of spectroscopic data analysis, including 1D/2D NMR techniques and compared with reported data from the literature. The isolated compound was subjected to antiproliferative potential activity against cancer cell lines of the liver (HepG-2), colon (HCT-116) and breast (MCF-7) using 3-[4,5-Dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) reduction Assay. As well as, the total extract of S. herba-alba and the purified 11-epiartapshin were tested for antimicrobial activity. 11-Epiartapshin showed moderate antibacterial effects against Gram-positive, Gram-negative bacteria and weak antifungal effect. Seriphidiumherba-alba total extract has good inhibitory activity against all tested pathogenic bacteria.

Keywords