Design and Synthesis of Hydrazide-Hydrazones Based 2-Oxonicotinonitrile Derivatives as Potential Antimicrobial Agents

El-Sayed, H. A.; Moustafa, A. H.; Awad, H. M.; Abd El-Moneim, M.; Esmat, A.

doi:10.18576/jpac/040207

Design and Synthesis of Hydrazide-Hydrazones Based 2-Oxonicotinonitrile Derivatives as Potential Antimicrobial Agents

Document Type : Original Article

Authors

¹ Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt.

² Department of Tanning Materials and Leather Technology, National Research Centre, Dokki 12622, Cairo, Egypt.

³ Department of Chemistry, Faculty of Science, Port Said University, Port Said, Egypt.

10.18576/jpac/040207

Abstract

Synthesis and antimicrobial screening of new series of hydrazide-hydrazones were described. Where, regiospacific alkylation of 2-oxonicotinonitriles1a,b with ethyl bromoacetate followed by hydrozinolys is afforded acetic acid hydrazides3a,b. The latter compounds were condensed with a variety of carbonyl containing compounds to give the target compounds of hydrazide- hydrazone derivatives 4a,b, 5a,b and6a-h. While, reaction of 3 a,b with acetyl acetone gave pyrazole derivatives7a,b. The antimicrobial activity of the new synthesized compounds 4b, 5c, 5e and 6bshowed a good activity against tested fungi (Aspergillus niger), while, all the tested compounds have a good and moderate activity against G (+ve) and G (-ve) bacteria.

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