Design, Synthesis and Hypolipidemic Activity of Novel Hydrazones of Nicotinic acid Hydrazide

O. Aboelez, Moustafa; M. Elhady, Omar M. Elhady; S. A. Shaykoon, Montaser; E.Shoman, Mai; A. Ahmed, Sanaa; A. Abuo-Rahma, Gamal El-Din

doi:10.18576/jpac/020304

Design, Synthesis and Hypolipidemic Activity of Novel Hydrazones of Nicotinic acid Hydrazide

Document Type : Original Article

Authors

¹ 1Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, 61519-Egypt. 2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, Sohag, 82524-Egypt.

² Department of Chemistry, Faculty of Science, Sohag University, Sohag, 82524-Egypt.

³ Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-AzharUniversity, Assiut, 71524-Egypt.

⁴ Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, 61519-Egypt.

⁵ Department of Pharmacology, Faculty of Medicine, Sohag University, Sohag, 82524-Egypt.

10.18576/jpac/020304

Abstract

Synthesis of novel N-acyl hydrazones of nicotinic acid hydrazide via condensation of nicotinic acid hydrazide 3 with the corresponding aldehydes 1, 2 are described. Their hypolipidemic activities were evaluated in high cholesterol diet fed rat model. The hydrazones were found to decrease the levels of serum total cholesterol, LDL cholesterol and triglycerides in hyperlipidemic rats to a greater degree than the reference gemfibrozil.

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