Department of Chemistry, Faculty of Education, Ain Shams University, Roxy 11711, Cairo, Egypt.
10.18576/jpac/020308
Abstract
variety of heteroannulated chromeno[2,3-b]pyridines and their related compounds were efficiently synthesized from chemical transformations of 6-methylchromone-3-carbonitrile (1) with some cyclic and acyclic carbon nucleophiles. Also, the reactivity of carbonitrile 1 was studied towards 1-ethyl-4-hydroxy-3-nitroacetylquinolin-2(1H)-one (8) producing the unexpected 5-ethyl-10-methyl-8H-benzo[h]chromeno[2,3-b][1,6]naphthyridine-6(5H),8-dione (9). A diversity of 2-substituted-3-cyclohexyl-8-methyl-4H,6H-chromeno[3',2':5,6]pyrido[2,3-d]pyrimidine-4,6-diones were synthesized. Structures of the newly synthesized products have been deduced on the basis of elemental analysis and spectral data. The newly prepared compounds were screened for their antimicrobial activity.
M. El-Gohary, N., A. Ibrahim, M., Gabr, Y., & Said, S. (2016). Synthesis and Antimicrobial Evaluation of Some Annulated Chromeno[2,3-b]Pyridines using 6-Methylchromone-3-Carbonitrile. Journal of Pharmaceutical and Applied Chemistry, 2(3), 28-34. doi: 10.18576/jpac/020308
MLA
Nasser M. El-Gohary; Magdy A. Ibrahim; Yassin Gabr; Sara Said. "Synthesis and Antimicrobial Evaluation of Some Annulated Chromeno[2,3-b]Pyridines using 6-Methylchromone-3-Carbonitrile". Journal of Pharmaceutical and Applied Chemistry, 2, 3, 2016, 28-34. doi: 10.18576/jpac/020308
HARVARD
M. El-Gohary, N., A. Ibrahim, M., Gabr, Y., Said, S. (2016). 'Synthesis and Antimicrobial Evaluation of Some Annulated Chromeno[2,3-b]Pyridines using 6-Methylchromone-3-Carbonitrile', Journal of Pharmaceutical and Applied Chemistry, 2(3), pp. 28-34. doi: 10.18576/jpac/020308
VANCOUVER
M. El-Gohary, N., A. Ibrahim, M., Gabr, Y., Said, S. Synthesis and Antimicrobial Evaluation of Some Annulated Chromeno[2,3-b]Pyridines using 6-Methylchromone-3-Carbonitrile. Journal of Pharmaceutical and Applied Chemistry, 2016; 2(3): 28-34. doi: 10.18576/jpac/020308
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